437 Results for "

Valeriana officinalis Linn. var. latifolia Miq.

" in MedChemExpress (MCE) Product Catalog:

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Silvestrol

53 Publications Verification

Cat. No.: HY-13251

CAS No.: 697235-38-4

Purity: 99.96%

Synonyms: (-)-Silvestrol

Category:

Agave americana Linn. Natural Products Agavaceae Plants Disease Research Fields Cancer

Target:

Eukaryotic Initiation Factor (eIF) Apoptosis Autophagy

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis .

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Geniposide

20 Cited Publications

Cat. No.: HY-N0009

CAS No.: 24512-63-8

Category:

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

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Morusin

14 Cited Publications

Cat. No.: HY-N0622

CAS No.: 62596-29-6

Synonyms: Mulberrochromene

Category:

Anti-aging Flavones Plants Infection other families Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

NF-κB STAT Bacterial

Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

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Vitexin

14 Cited Publications

Cat. No.: HY-N0013

CAS No.: 3681-93-4

Category:

Cardiovascular Disease Neurological Disease Anti-aging Flavones Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Trigonella foenum-graecum Linn. Cancer

Target:

Autophagy

Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

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Hematoxylin

11 Cited Publications

Cat. No.: HY-N0116

CAS No.: 517-28-2

Synonyms: Natural Black 1; Haematoxylin

Category:

Leguminosae Caesalpinia sappan L. Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:

Amyloid-β

Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC₅₀ of 1.6 μM.

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Chaetocin

10 Cited Publications

Cat. No.: HY-N2019

CAS No.: 28097-03-2

Category:

Infection Alkaloids Microorganisms Disease Research Fields Alkaloid Dimers

Target:

Histone Methyltransferase Bacterial Antibiotic

Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC₅₀ of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC₅₀ of 4 μM.

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Isobavachalcone

10 Cited Publications

Cat. No.: HY-13065

CAS No.: 20784-50-3

Purity: 99.01%

Synonyms: Corylifolinin; Isobacachalcone

Category:

Plants Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:

Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy

Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

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Magnolol

8 Cited Publications

Cat. No.: HY-N0163

CAS No.: 528-43-8

Category:

Cardiovascular Disease Neurological Disease Lignans Plants Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:

RAR/RXR PPAR Autophagy Bacterial

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

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Cornuside

7 Cited Publications

Cat. No.: HY-N0631

CAS No.: 131189-57-6

Category:

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:

Free Radical Scavengers p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC₅₀ = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .

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Syringaldehyde

5 Cited Publications

Cat. No.: HY-N1390

CAS No.: 134-96-3

Category:

Microorganisms Monophenols Ketones, Aldehydes, Acids Manihot esculenta Crantz Phenols Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology

Target:

COX

Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis . Syringaldehyde moderately inhibits COX-2 activity with an IC₅₀ of 3.5 μg/mL . Anti-hyperglycemic and anti-inflammatory activities .

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Asparagusic acid

4 Cited Publications

Cat. No.: HY-50730

CAS No.: 2224-02-4

Category:

Infection Liliaceae Ketones, Aldehydes, Acids Plants Disease Research Fields Asparagus officinalis L.

Target:

Parasite Endogenous Metabolite

Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor .

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Corosolic acid

4 Cited Publications

Cat. No.: HY-N0280

CAS No.: 4547-24-4

Synonyms: Colosolic acid

Category:

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:

Autophagy Apoptosis EGFR

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis .

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Monotropein

3 Cited Publications

Cat. No.: HY-N0648

CAS No.: 5945-50-6

Category:

Iridoids Pyrola calliantha H. Andr. Terpenoids Pyrolaceae Rubiaceae Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology

Target:

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .

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Methyl vanillate

2 Cited Publications

Cat. No.: HY-75342

CAS No.: 3943-74-6

Category:

Microorganisms Monophenols Oryza sativa Linn. Gramineae Phenols Plants

Target:

Wnt Reactive Oxygen Species (ROS) Endogenous Metabolite

Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

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Vitexin (Standard)

2 Cited Publications

Cat. No.: HY-N0013R

CAS No.: 3681-93-4

Category:

Flavonoids Leguminosae Flavones Phenols Polyphenols Plants Trigonella foenum-graecum Linn.

Target:

Reference Standards Autophagy

Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

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Dryocrassin ABBA

2 Cited Publications

Cat. No.: HY-N0530

CAS No.: 12777-70-7

Synonyms: Dryocrassin

Category:

Infection Dryopteridaceae Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields

Target:

Apoptosis Influenza Virus

Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase .

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Moracin O

2 Cited Publications

Cat. No.: HY-N3244

CAS No.: 123702-97-6

Category:

Neurological Disease Phenols Polyphenols Plants Moraceae Disease Research Fields Inflammation/Immunology Morus alba Linn.

Target:

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)

Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects .

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Glaucocalyxin A

2 Cited Publications

Cat. No.: HY-N2112

CAS No.: 79498-31-0

Category:

Labiatae Terpenoids Diterpenoids Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer

Target:

PI3K Akt Apoptosis

Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .

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Cinchonidine

2 Cited Publications

Cat. No.: HY-N0173

CAS No.: 485-71-2

Synonyms: α-Quinidine

Category:

Infection Alkaloids Piperidine Alkaloids Cinchona officinalis Linn. Rubiaceae Quinoline Alkaloids Plants Disease Research Fields

Target:

Serotonin Transporter Parasite

Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with K_is of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities .

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Verbenalin

2 Cited Publications

Cat. No.: HY-N2014

CAS No.: 548-37-8

Category:

Infection Iridoids Verbenaceae Terpenoids Verbena officinalis Linn. Plants Disease Research Fields Inflammation/Immunology

Target:

SARS-CoV Amyloid-β Ferroptosis Tau Protein Caspase Bcl-2 Family

Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease .

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